Leadership
Dr. Jordan J. Green
Biomedical Engineer · Co-Founder
Biomedical engineer and inventor whose biodegradable nanoparticle technologies form the foundation of Dome Therapeutics' drug delivery platform.
Biography
Dr. Jordan J. Green is the Herschel L. Seder Professor and Vice Chair for Research & Translation in Biomedical Engineering at Johns Hopkins, with joint appointments in Oncology, Neurosurgery, Ophthalmology, Materials Science, and Chemical & Biomolecular Engineering.
His lab builds biodegradable nanoparticles that deliver DNA, RNA, and proteins to targeted cells. At Dome, he leads the nanoparticle delivery platform for brain cancer.
Focus
Research Interests
- Biomaterials
- Biodegradable polymer nanoparticles
- Drug delivery
- Gene therapy
- mRNA delivery
- siRNA delivery
- Cancer nanomedicine
- Immunotherapy
- Cellular engineering
- Regenerative medicine
- Controlled drug delivery
- Nanobiotechnology
Research
Selected Publications
Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion
Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis
Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells
Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells
Training
Education
B.S., Chemical Engineering
Carnegie Mellon University
B.S., Biomedical Engineering
Carnegie Mellon University
Ph.D., Biological Engineering
Massachusetts Institute of Technology (MIT)
Postdoctoral Associate, Chemical Engineering
Massachusetts Institute of Technology (MIT)
Recognition
Awards & Honors
Presidential Early Career Award for Scientists and Engineers (PECASE)
AIChE Allan P. Colburn Award
BMES Rita Schaffer Young Investigator Award
American Society of Gene & Cell Therapy Outstanding New Investigator Award
TERMIS Americas Young Investigator Award
Popular Science Brilliant Ten
Carnegie Mellon Recent Alumni Award
Maryland Outstanding Young Engineer Award
Clemson Award for Applied Research (Society For Biomaterials)
Career
Professional Experience
- Present
Co-Founder
Dome Therapeutics
- Present
Herschel L. Seder Professor
Johns Hopkins University
- Present
Vice Chair for Research & Translation, Department of Biomedical Engineering
Johns Hopkins University
- Present
Professor of Biomedical Engineering; Oncology; Neurosurgery; Ophthalmology; Materials Science & Engineering; Chemical & Biomolecular Engineering
Johns Hopkins University
- Present
Director, Biomaterials & Drug Delivery Laboratory
Johns Hopkins University
- Present
Founding Associate Director, Translational Tissue Engineering Center
Johns Hopkins University
- Present
Founding Associate Director, NCBIB Translational ImmunoEngineering Center
Johns Hopkins University
- Present
Executive Committee Member
Institute for NanoBioTechnology
Ventures
Innovation & Entrepreneurship
- Present
Co-Founder
Dome Therapeutics
- Present
Co-Founder & Chief Technology Officer
AsclepiX Therapeutics
Inventor on numerous issued and pending patents involving biomaterials, nanoparticle drug delivery, and gene delivery technologies.
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